**Question:** Sclerodema like disorder is/are caused by

A. Autoimmune disorders
B. Infections
C. Chronic inflammation
D. Medication side effects

**Core Concept:** Scleroderma is a group of connective tissue diseases characterized by excessive collagen deposition leading to fibrosis and hardening of the skin and internal organs. There are two main types of scleroderma: systemic sclerosis (SSc) and localized scleroderma.

**Why the Correct Answer is Right:** Sclerodema-like disorders are primarily caused by the involvement of the immune system, which leads to inflammation and fibrosis. The correct answer, "Autoimmune disorders," encompasses this aspect as it refers to conditions where the immune system mistakenly attacks the body's own tissues, including those in the skin and internal organs.

**Why Each Wrong Option is Incorrect:**

A. **Infections:** While infections can occasionally cause a scleroderma-like response (e.g., bacterial endocarditis, leprosy), these options are not the primary cause of sclerodema-like disorders.

B. **Chronic inflammation:** While inflammation plays a role in scleroderma pathogenesis, it is not the primary cause. Autoimmune disorders are the primary culprit, as mentioned above.

C. **Medication side effects:** Medications can cause a scleroderma-like response, but they are not the primary cause of sclerodema-like disorders. Autoimmune disorders are more likely to be the underlying issue.

**Clinical Pearl:** Scleroderma-like disorders are usually caused by an autoimmune response, which is why the correct answer is "Autoimmune disorders." Understanding the underlying cause is essential for proper diagnosis and treatment of these conditions.

**Correct Answer:** Autoimmune disorders