Which of the following is seen in Schwannoma?
**Core Concept**
Schwannoma, also known as neurilemmoma, is a benign tumor that arises from the Schwann cells of the peripheral nervous system. It is a type of nerve sheath tumor that typically affects the cranial nerves, particularly the vestibulocochlear nerve (CN VIII), and the peripheral nerves.
**Why the Correct Answer is Right**
Schwannomas are characterized by the presence of Antoni A and Antoni B areas. Antoni A areas are compact, highly cellular regions with palisading nuclei, while Antoni B areas are loose, myxoid regions with dispersed cells. This biphasic pattern is a hallmark of Schwannoma. The tumor cells in Schwannoma express S-100 protein, which is a useful immunohistochemical marker for diagnosis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the histological features of Schwannoma. While some tumors may exhibit a similar appearance, the biphasic pattern of Antoni A and Antoni B areas is a distinctive feature of Schwannoma.
**Option B:** This option is incorrect because it is not a characteristic of Schwannoma. While some tumors may exhibit necrosis, it is not a typical feature of Schwannoma.
**Option C:** This option is incorrect because it is not a specific feature of Schwannoma. While some tumors may exhibit a similar appearance under the microscope, the presence of Antoni A and Antoni B areas is a hallmark of Schwannoma.
**Clinical Pearl / High-Yield Fact**
Schwannomas are typically benign tumors, but they can cause significant clinical symptoms due to their location and growth pattern. They often present with symptoms related to the affected nerve, such as hearing loss, tinnitus, or facial weakness.
**Correct Answer:** C.