**Core Concept**
Good prognosis in schizophrenia is associated with positive symptoms, acute onset, and a clear family history. Patients with a good prognosis tend to have a more favorable response to treatment and a lower risk of relapse.

**Why the Correct Answer is Right**
The correct answer is related to the concept of "Type I" schizophrenia, characterized by a good prognosis. This subtype is associated with a clear family history of schizophrenia, acute onset of symptoms, and a predominance of positive symptoms such as hallucinations and delusions. Patients with Type I schizophrenia tend to have a more favorable response to treatment, including antipsychotic medications, and a lower risk of relapse.

**Why Each Wrong Option is Incorrect**
**Option A:** This option may be tempting, but a family history of schizophrenia is actually a negative prognostic factor. Patients with a family history of schizophrenia tend to have a poorer response to treatment and a higher risk of relapse.
**Option B:** Chronic course is actually a negative prognostic factor in schizophrenia. Patients with a chronic course tend to have a poorer response to treatment and a higher risk of relapse.
**Option C:** Negative symptoms, such as apathy and social withdrawal, are actually a negative prognostic factor in schizophrenia. Patients with a predominance of negative symptoms tend to have a poorer response to treatment and a higher risk of relapse.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the prognostic factors in schizophrenia can be categorized into two main types: Type I (good prognosis) and Type II (poor prognosis). Patients with Type I schizophrenia tend to have a clear family history, acute onset of symptoms, and a predominance of positive symptoms.

**Correct Answer: C. Negative symptoms are a poor prognostic factor in schizophrenia.**