**Core Concept**
Negative symptoms in schizophrenia, such as apathy, social withdrawal, and lack of motivation, are distinct from positive symptoms like hallucinations and delusions. These symptoms can significantly impact the patient's quality of life and functional ability. Research has shown that negative symptoms are often associated with a poorer prognosis and more severe illness course.

**Why the Correct Answer is Right**
Negative symptoms in schizophrenia are generally associated with a poorer prognosis due to their impact on social and occupational functioning. Patients with prominent negative symptoms tend to have more difficulty recovering from their illness and may require more intensive treatment. This is because negative symptoms can be more resistant to traditional antipsychotic medications and may require additional therapies, such as cognitive-behavioral therapy or social skills training.

**Why Each Wrong Option is Incorrect**
**Option A:** Late onset schizophrenia is often associated with a better prognosis than early-onset schizophrenia. This is because patients with late-onset schizophrenia tend to have fewer cognitive and functional impairments and may be more responsive to treatment.
**Option B:** Being married has been linked to a better prognosis in schizophrenia, possibly due to the social support and stability that comes with a committed relationship. Married individuals with schizophrenia may also be more likely to adhere to treatment and engage in therapy.
**Option D:** Acute onset schizophrenia, characterized by a sudden and dramatic onset of symptoms, is often associated with a better prognosis than insidious onset schizophrenia. This is because acute onset patients may be more likely to receive early treatment and may respond more quickly to interventions.

**Clinical Pearl / High-Yield Fact**
When evaluating a patient with schizophrenia, it's essential to assess not only the presence and severity of symptoms but also the patient's level of social support and functional ability. This can help clinicians identify patients who may benefit from additional therapies or interventions to improve their prognosis.

✓ Correct Answer: C. Negative symptoms