Schilling’s test is false + ve in (PGI June 2008)
**Core Concept**
Schilling's test is a medical investigation used to assess the absorption of vitamin B12. It involves measuring the amount of radioactive vitamin B12 excreted in the urine after oral administration. The underlying principle being tested is the body's ability to absorb vitamin B12, which is crucial for the production of red blood cells.
**Why the Correct Answer is Right**
Although the correct answer is not specified, Schilling's test can be false positive in certain conditions. For example, if a patient has a urinary obstruction or renal failure, they may not be able to excrete the radioactive vitamin B12, leading to a false positive result.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the actual options, it's challenging to provide specific reasons for each incorrect choice.
**Option B:** Typically, other conditions such as pancreatic insufficiency or bacterial overgrowth might affect the test, but without the options, it's hard to assess.
**Option C:** Certain medications can interfere with the test, but again, the specifics depend on the options provided.
**Option D:** Similarly, other factors like diet or recent gastrointestinal surgery could potentially impact the test results.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that Schilling's test is used to diagnose pernicious anemia, a condition characterized by the deficiency of intrinsic factor, which is necessary for vitamin B12 absorption.
**Correct Answer:** Incorrect format, answer not provided.