Russel bodies seen in
**Question:** Russel bodies seen in
A. Immunopositive granules in mast cells
B. Ribosomes in eukaryotic cells
C. Membrane-bound granules in neutrophils
D. Ribosomes in cytoplasm of eukaryotic cells
**Core Concept:**
Russell bodies, also known as Russell-Silver granules or IgE-containing granules, are granules found in the cytoplasm of activated mast cells. These granules contain immunoglobulin E (IgE) and are involved in the allergic response and immune system activation. Mast cells are a type of white blood cell that plays a crucial role in the defense against pathogens, tissue repair, and allergic reactions.
**Why the Correct Answer is Right:**
Correct answer A (Immunopositive granules in mast cells) highlights the fundamental role of Russell bodies in mast cells. IgE, the immunoglobulin found in these granules, is responsible for the immediate hypersensitivity reactions, which are a crucial aspect of the immune response. The presence of IgE in Russell bodies allows mast cells to react swiftly and effectively against parasites, allergens, and pathogens.
**Why Each Wrong Option is Incorrect:**
Option B (Ribosomes in eukaryotic cells) is incorrect because ribosomes are essential components of eukaryotic cells involved in protein synthesis, not granules containing immunoglobulins.
Option C (Membrane-bound granules in neutrophils) is incorrect because neutrophils are a different type of white blood cell, primarily involved in phagocytosis and bacterial defense, not the storage of IgE-containing granules like Russell bodies.
Option D (Ribosomes in cytoplasm of eukaryotic cells) is incorrect as mentioned above, as ribosomes are involved in protein synthesis, not storage of immunoglobulins.
**Core Concept:**
Russell bodies are granules found in activated mast cells, which contain immunoglobulin E (IgE) and play a crucial role in the immune response. These granules are part of the mast cell's immediate hypersensitivity reaction, which is essential for combating pathogens, parasites, and allergens.
**Why the Correct Answer is Right:**
The correct answer, option A (Immunopositive granules in mast cells), highlights the specific granules containing IgE, which allows mast cells to respond promptly and effectively against parasites, antigens, and pathogens.
**Why Each Wrong Option is Incorrect:**
Option B (Ribosomes in eukaryotic cells) is incorrect because ribosomes are involved in protein synthesis, not storing immunoglobulins like IgE in Russell bodies.
Option C (Membrane-bound granules in neutrophils) is incorrect because neutrophils are involved in phagocytosis and bacterial defense, not IgE storage in Russell bodies.
Option D (Ribosomes in cytoplasm of eukaryotic cells) is incorrect, as mentioned earlier, since ribosomes are involved in protein synthesis, not IgE storage in Russell bodies.