Rubeosis iridis is not seen in:
**Core Concept**
Rubeosis iridis, also known as neovascularization of the iris, is a condition characterized by the growth of new, fragile blood vessels on the surface of the iris. This occurs in response to ischemia or hypoxia, leading to the release of angiogenic factors that stimulate vascular endothelial growth factor (VEGF) production.
**Why the Correct Answer is Right**
Rubeosis iridis is typically associated with conditions that cause ischemia or hypoxia, such as diabetic retinopathy, retinal vein occlusion, and central retinal artery occlusion. The growth of new blood vessels on the iris is a result of the body's attempt to compensate for the lack of oxygen and nutrients in the retina. The neovascularization process is mediated by the release of growth factors, including VEGF, which promotes angiogenesis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because rubeosis iridis can be seen in conditions that cause ischemia or hypoxia, such as diabetic retinopathy.
**Option B:** This option is incorrect because rubeosis iridis is not typically associated with conditions that cause inflammation, such as uveitis.
**Option C:** This option is incorrect because rubeosis iridis can be seen in conditions that cause retinal detachment, such as retinal tears or lattice degeneration.
**Clinical Pearl / High-Yield Fact**
Rubeosis iridis is a significant clinical finding that requires prompt attention, as it can lead to complications such as angle closure glaucoma, vitreous hemorrhage, and retinal detachment.
**Correct Answer: B. Uveitis.**