Route of administration of Gn RH analogue –
**Core Concept**
The route of administration of Gonadotropin-Releasing Hormone (GnRH) analogues is crucial for their therapeutic effects. GnRH analogues are used to treat conditions like prostate cancer, precocious puberty, and infertility. They can be administered via various routes to achieve desired effects.
**Why the Correct Answer is Right**
GnRH analogues are typically administered subcutaneously or intramuscularly to achieve a sustained release of the drug. This route allows for a steady and consistent level of the hormone in the bloodstream, which is essential for their therapeutic effects.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect as oral administration is not a common route for GnRH analogues due to poor bioavailability.
**Option B:** Incorrect as intravenous administration is not typically used for GnRH analogues.
**Option D:** Incorrect as topical administration is not a standard route for GnRH analogues.
**Clinical Pearl / High-Yield Fact**
GnRH analogues can be used to treat endometriosis and uterine fibroids by inducing a temporary menopausal state.
**Correct Answer:** D. Subcutaneous/Intramuscular.