Rossmann fold associated NADH domain is found in which enzyme?
Correct Answer: Lactate dehydrogenase
Description: Lactate dehydrogenase is comprised of two domains, an N-terminal NAD+ -binding domain and a C-terminal binding domain for the second substrate, pyruvate. Lactate dehydrogenase is one of the family of oxidoreductases that share a common N-terminal NAD(P)+ -binding domain known as the Rossmann fold. By fusing a segment of DNA coding for a Rossmann fold domain to that coding for a variety of C-terminal domains, a large family of oxidoreductases have evolved that utilize NAD(P)+ /NAD(P)H for the oxidation and reduction of a wide range of metabolites.
Ref: Harper’s illustrated biochemistry. 30th edition page no: 40
Category:
Biochemistry
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