Rossman fold associated NADH domain is found in which of the following enzyme:
Correct Answer: Isocitrate Dehydrogenase
Description: Rossmann fold bab fold- a super-secondary structure Named after Michael Rossmann Characterized by an alternating bab (beta strand-alpha helix-beta strand) The bab fold structure is commonly observed in enzymes that have dinucleotide coenzymes(FAD, SAM, NAD and NADP) Found in a lot of dehydrogenase enzymes towards N-terminal end. It is also found in alcohol dehydrogenase enzyme The enzymes which have Rossmann fold are known as Rossmann enzymes e.g. Glyceraldehyde-3-Phosphate Dehydrogenase Alcohol Dehydrogenase Isocitrate Dehydrogenase Lactate Dehydrogenase Phosphoglycerate Dehydrogenase Glutathione Reductase D-AminoAcid Oxidase
Category:
Biochemistry
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