Congenital Rubella Syndrome (CRS):CRS is said to have occurred if:– Infant has IgM rubella antibodies shortly after birth, or – IgG antibodies persist for more than 6 monthsMajor determinant of extent of fetal infection in CRS: Gestational age at which fetal transmission occurs,– Infection in I trimester: MOST DISASTROUS TIME 1. Abortions 2. Still births 3. Skin lesions: blueberry muffin lesions 4. ‘Triad of Congenital Rubella Syndrome’ i. Sensorineural deafness ii. Congenital heart defects (MC is PDA) iii. Cataracts – Infection in early part of II Trimester: Deafness (only) – Infection after 16 weeks POG: No major abnormalities Risk of fetal damage in CRS: