Risk Factors for Cancer in Ulcerative Colitis patient • The duration of colitis • The extent of colonic involvement • The presence of concomitant PSC and family history of CRC (regardless of the family history of IBD) • Pancolitis (disease extending proximal to the splenic flexure) and disease diagnosed at a young age • UC-related CRC tends to be multicentric and evenly distributed throughout the colon. Tumour tend to be infiltrative, highly aggressive and poorly differentiated. • No significant difference between sporadic and UC-related CRC with respect to prognosis.