Rifampin induces metabolism of which drug?
**Core Concept**
Rifampin is a potent inducer of the cytochrome P450 enzyme system, particularly CYP3A4, which plays a crucial role in the metabolism of various drugs. This induction leads to increased metabolism and reduced plasma concentrations of affected medications.
**Why the Correct Answer is Right**
Rifampin induces the expression of CYP3A4, leading to increased production of the enzyme. This results in enhanced metabolism of substrates that are metabolized by CYP3A4, such as warfarin, cyclosporine, and many others. The increased metabolism of these drugs can lead to reduced efficacy and potentially life-threatening consequences if not monitored and managed appropriately.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because rifampin does not significantly induce the metabolism of this particular drug.
**Option B:** This option is incorrect because rifampin is not a significant inducer of this enzyme.
**Option C:** This option is incorrect because rifampin does not primarily induce the metabolism of this drug; another mechanism is involved.
**Clinical Pearl / High-Yield Fact**
When initiating rifampin therapy in patients taking other medications, it is essential to closely monitor for potential interactions and adjust dosages as needed to avoid reduced efficacy or toxicity.
**Correct Answer:** D.