**Core Concept**
Orbital Rhabdomyosarcoma is a malignant tumor of the orbit, primarily affecting children and young adults. It originates from skeletal muscle cells, which are a type of mesenchymal cell. This tumor is characterized by its aggressive behavior and potential for metastasis.

**Why the Correct Answer is Right**
Orbital Rhabdomyosarcoma is more common in males, with a male-to-female ratio of approximately 3:1 or 4:1. This gender predilection is thought to be related to the higher expression of androgen receptors in the tumor cells of male patients. The tumor's aggressive behavior and potential for metastasis necessitate prompt and accurate diagnosis, often through imaging studies and biopsy.

**Why Each Wrong Option is Incorrect**
**Option A:** The statement that Orbital Rhabdomyosarcoma arises from pluripotent stem cells is incorrect. While pluripotent stem cells are the precursors to various cell types, Orbital Rhabdomyosarcoma specifically originates from skeletal muscle cells, which are a more differentiated cell type.
**Option B:** The statement that Orbital Rhabdomyosarcoma originates from skeletal muscle cell is correct, but the question asks for the wrong statement. However, to maintain the format, we acknowledge that this option is not incorrect.
**Option C:** The statement that Orbital Rhabdomyosarcoma has a unilateral preponderance is correct, as the tumor typically presents in one orbit. However, this option is not the incorrect statement being asked for.

**Clinical Pearl / High-Yield Fact**
Orbital Rhabdomyosarcoma often presents with proptosis, eyelid swelling, and diplopia due to the tumor's mass effect on the orbit. Prompt recognition and referral to a specialist are crucial for timely diagnosis and treatment, as this tumor can be highly aggressive and resistant to treatment if left untreated.

**✓ Correct Answer: D. More common in females**