Rh-isoimmunization in pregnancy can cause all except :
**Core Concept**
Rh-isoimmunization in pregnancy occurs when an Rh-negative mother is exposed to Rh-positive red blood cells from her Rh-positive fetus, leading to the formation of antibodies against Rh-positive blood. This can cause hemolytic disease of the newborn (HDN), where the mother's immune system attacks the fetus's red blood cells.
**Why the Correct Answer is Right**
The correct answer is related to the consequences of Rh-isoimmunization. In Rh-isoimmunization, the mother's immune system produces antibodies against the Rh-positive blood of the fetus, leading to the breakdown of the fetus's red blood cells. This can cause anemia, jaundice, and even death in severe cases. The most severe manifestation of Rh-isoimmunization is HDN, which can lead to fetal hydrops, cardiac failure, and even stillbirth.
**Why Each Wrong Option is Incorrect**
**Option A:** Not relevant to Rh-isoimmunization. While anemia is a possible consequence of Rh-isoimmunization, it is not the most direct or severe manifestation.
**Option B:** Not directly related to Rh-isoimmunization. While jaundice can be a consequence of Rh-isoimmunization, it is not the most specific or severe manifestation.
**Option C:** This is the correct answer. Rh-isoimmunization can cause hemolytic disease of the newborn (HDN), but it does not directly cause cardiac failure or stillbirth in the fetus.
**Option D:** Not a direct consequence of Rh-isoimmunization. While stillbirth can be a consequence of severe Rh-isoimmunization, it is not the most specific or direct manifestation.
**Clinical Pearl / High-Yield Fact**
To prevent Rh-isoimmunization, Rh-negative mothers should receive Rh immunoglobulin (RhIg) within 72 hours of delivery and at 28 weeks of gestation. This can prevent the formation of antibodies against Rh-positive blood and reduce the risk of HDN.
**Correct Answer:** C