## Core Concept
Rett's syndrome is a genetic disorder that primarily affects girls, causing severe mental and physical disability. It is characterized by normal early growth and development followed by a slowing of development, intellectual disability, and physical disability. The disorder is caused by mutations in the MECP2 gene.

## Why the Correct Answer is Right
The correct answer, , is associated with macrocephaly, which is not a characteristic feature of Rett's syndrome. In fact, individuals with Rett's syndrome typically have microcephaly (small head size).

## Why Each Wrong Option is Incorrect
* **Option A:** - This option is incorrect because individuals with Rett's syndrome do exhibit hand wringing and other repetitive hand movements.
* **Option B:** - This option is incorrect because loss of social interaction and communication skills is a hallmark of Rett's syndrome.
* **Option C:** - This option is incorrect because seizures are a common feature in Rett's syndrome.

## Clinical Pearl / High-Yield Fact
A key clinical feature to remember about Rett's syndrome is the presence of **hand wringing** and the development of **microcephaly**. These are critical diagnostic features that distinguish Rett's syndrome from other neurodevelopmental disorders.

## Correct Answer: D. Macrocephaly