## Core Concept
Retinopathy of prematurity (ROP) is a disease of the eye affecting prematurely born babies generally having birth weight less than 1250 grams or gestational age less than 31 weeks. It is a significant cause of childhood blindness. The condition involves abnormal growth of retinal blood vessels.

## Why the Correct Answer is Right
The correct answer, , is related to the risk factors of ROP. Gestational age less than 31 weeks and birth weight less than 1250 grams are well-established risk factors. Maternal preeclampsia and multiple gestations are also associated with an increased risk of ROP. However, a higher birth weight is not a risk factor; in fact, lower birth weights are associated with a higher risk.

## Why Each Wrong Option is Incorrect
* **Option A:** Low birth weight (<1250g) is a known risk factor for ROP. Premature infants with low birth weight are at a higher risk. * **Option B:** Gestational age < 31 weeks is a risk factor. The earlier the gestational age, the higher the risk of developing ROP. * **Option D:** Maternal preeclampsia is considered a risk factor. Preeclampsia can affect fetal growth and development, potentially increasing the risk for ROP. ## Clinical Pearl / High-Yield Fact A key point to remember is that ROP is a leading cause of preventable childhood blindness. Early screening and detection are crucial in preterm infants. The American Academy of Pediatrics recommends ROP screening for all infants born at <31 weeks gestational age or with a birth weight of ≤1250 grams. ## Correct Answer: D. Higher birth weight.