**Core Concept**
Retinoblastoma is a malignant tumor of the retina, primarily affecting children. It arises from the primitive neuroectodermal cells in the retina, leading to the formation of a malignant mass. The tumor is characterized by the presence of anaplastic cells, which exhibit rapid growth and invasion.

**Why the Correct Answer is Right**
Retinoblastoma is most similar to neuroblastoma, another malignant tumor of neural crest origin. Both tumors share similar histological features, such as small, round, blue cells and a tendency to metastasize. In both cases, the primitive neuroectodermal cells give rise to the malignant tumor. The genetic mutations responsible for retinoblastoma (RB1 gene) and neuroblastoma (MYCN gene) are also similar, highlighting the shared pathogenesis of these two tumors.

**Why Each Wrong Option is Incorrect**
**Option A:** Medulloblastoma - While both are malignant tumors of the central nervous system, medulloblastoma arises from the cerebellum and has a distinct histological appearance and genetic profile.
**Option B:** Meningioma - Meningioma is a benign tumor of the meninges, and its histological features and clinical behavior are quite different from those of retinoblastoma.
**Option C:** Optic nerve glioma - Optic nerve glioma is a type of low-grade astrocytoma that affects the optic nerve, and its clinical presentation and histological features are distinct from those of retinoblastoma.

**Clinical Pearl / High-Yield Fact**
Retinoblastoma is a highly malignant tumor that requires prompt treatment to prevent vision loss and metastasis. Early detection through regular eye exams is crucial for successful management.

**Correct Answer: C. Optic nerve glioma.**