**Core Concept**
Retinoblastoma is a malignant tumor of the retina, primarily affecting children. It arises from the immature retinal cells, often due to mutations in the RB1 tumor suppressor gene. The development of retinoblastoma is a classic example of a multistep carcinogenesis process.

**Why the Correct Answer is Right**
Retinoblastoma originates from the neuroblastic layer of the retina, specifically from the undifferentiated retinal cells. The RB1 gene plays a crucial role in regulating the cell cycle and preventing uncontrolled cell division. Mutations in the RB1 gene lead to the loss of its tumor suppressor function, ultimately resulting in the development of retinoblastoma. The tumor cells exhibit a characteristic "flea's eye" appearance on histopathological examination.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because retinoblastoma is not associated with the optic nerve or the optic disc, which are distinct anatomical structures.
**Option B:** This option is incorrect because retinal detachment is a complication of retinoblastoma, not its primary origin.
**Option C:** This option is incorrect because retinoblastoma is not a tumor of the uveal tract, which includes the iris, ciliary body, and choroid.

**Clinical Pearl / High-Yield Fact**
Retinoblastoma often presents with leukocoria (white pupillary reflex), strabismus, or vision loss in the affected eye. Early detection and treatment are crucial to prevent the spread of the tumor and improve prognosis.

**Correct Answer:** C.