Major hormone secreted by zona reticularis of adrenal coex ?
**Core Concept**
The adrenal cortex is divided into three zones: zona glomerulosa, zona fasciculata, and zona reticularis. Each zone secretes distinct hormones that play crucial roles in maintaining homeostasis. The zona reticularis is the innermost layer, and its primary function is to produce androgens.
**Why the Correct Answer is Right**
The zona reticularis is responsible for the production of androgens, which are a group of sex hormones that include testosterone and dihydroepiandrosterone (DHEA). These hormones are essential for the development of male characteristics, such as facial hair and deep voice, and also play a role in the regulation of the reproductive system. Androgens are synthesized from cholesterol through a series of enzyme-catalyzed reactions, involving key enzymes such as 17-alpha-hydroxylase and 17,20-desmolase.
**Why Each Wrong Option is Incorrect**
**Option A:** Glucocorticoids are primarily secreted by the zona fasciculata, which is the middle layer of the adrenal cortex. They play a crucial role in regulating metabolism, immune response, and stress response.
**Option B:** Mineralocorticoids, specifically aldosterone, are produced by the zona glomerulosa, the outermost layer of the adrenal cortex. They help regulate electrolyte balance and blood pressure.
**Option C:** Aldosterone is a type of mineralocorticoid and is not produced by the zona reticularis. It is involved in sodium and potassium balance and is essential for maintaining proper blood pressure.
**Clinical Pearl / High-Yield Fact**
The adrenal glands produce a range of hormones, and dysfunction of any zone can lead to various clinical syndromes. For example, congenital adrenal hyperplasia (CAH) is a group of genetic disorders that affect the adrenal glands, leading to an overproduction or underproduction of hormones.
**β Correct Answer: D. Androgens**