**Core Concept**
Systemic vascular resistance (SVR) is a measure of the resistance to blood flow in the systemic circulation. It is calculated as the ratio of mean arterial pressure to cardiac output. An increase in SVR indicates increased peripheral resistance, which can lead to elevated blood pressure and decreased cardiac output.

**Why the Correct Answer is Right**
When SVR is twice that of normal, it indicates severe vasoconstriction or increased peripheral resistance. The primary treatment goal is to decrease SVR and improve cardiac output. This can be achieved by administering vasodilators, such as nitroglycerin or nitroprusside, which relax smooth muscle and increase blood flow to the periphery. Additionally, administering fluids and inotropes, such as dobutamine, can help increase cardiac output.

**Why Each Wrong Option is Incorrect**
**Option A:** Vasopressors, such as norepinephrine, would increase SVR further, exacerbating the condition.
**Option B:** Beta-blockers would decrease cardiac output and worsen the situation.
**Option C:** This option is incomplete and does not provide a viable treatment option.

**Clinical Pearl / High-Yield Fact**
In patients with increased SVR, it is essential to differentiate between vasodilatory shock (e.g., septic shock) and cardiogenic shock. Vasodilatory shock requires vasopressors to increase SVR, whereas cardiogenic shock requires inotropes to increase cardiac output.

**Correct Answer:** C. Administering vasodilators (e.g., nitroglycerin or nitroprusside) and inotropes (e.g., dobutamine) to decrease SVR and improve cardiac output.