Resistance to zidovudne develops due to:
Correct Answer: Mutation at reverse transcriptase
Description: Zidovudine;It is a thymidine analogue (azidothymidine, AZT), the prototype NI. After phosphorylation in the host cell-zidovudine triphosphate selectively inhibits viral reverse transcriptase (RNA-dependent DNA polymerase) in preference to cellular DNA polymerase Resistance to AZT occurs by point mutations which alter reverse transcriptase enzyme. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:770
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