Pharmacology Resistance to Methotrexate develops due to? A Rapid Cancer cell multiplication B Deficiency of thymidylate kinase C Deficiency of thymidylate synthetase D Increased production of dihydrofolate reductase 💡 Explanation Resistance to Methotrexate develops due to? ✓ Correct Answer: D. Increased production of dihydrofolate reductase