**Core Concept**
The question is testing the knowledge of dental development and the sequence of tooth eruption in humans. The permanent teeth develop and erupt in the jawbone, replacing the primary teeth. The timing and sequence of tooth eruption can vary, but there is a generally accepted pattern.

**Why the Correct Answer is Right**
The second molars are the last primary teeth to be replaced by permanent teeth. This is because the development of the second molars is delayed, and they erupt between the ages of 12 to 16 years. The second molars are located in the posterior region of the dental arch and are part of the primary dentition.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not specified, so we can't provide a reason why it's incorrect.
* **Option B:** This option is also not specified, so we can't provide a reason why it's incorrect.
* **Option C:** This option is not specified, so we can't provide a reason why it's incorrect.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the sequence of tooth eruption can vary among individuals, but the second molars are generally the last primary teeth to be replaced by permanent teeth.

**Correct Answer: C. Second molars are the last primary teeth to be replaced by permanent teeth.