Feature of Rhabdomyolysis -a) Present with acute muscular weaknessb) Calf muscles commonly rupturedc) Myoglobinuria d) Acute renal failure is most common e) Hemoglobinuria
## **Core Concept**
Rhabdomyolysis is a serious syndrome due to direct or indirect muscle injury. It results from the death of muscle fibers and release of their contents into the bloodstream, leading to various systemic complications. This condition can be caused by trauma, infections, drugs, and certain medical conditions.
## **Why the Correct Answer is Right**
The correct answer includes features commonly associated with rhabdomyolysis.
- **Acute muscular weakness (a)** is a presenting symptom as muscle damage leads to loss of muscle function.
- **Myoglobinuria (c)** occurs due to the breakdown of muscle cells releasing myoglobin, which then passes into the urine, giving it a characteristic color.
- **Acute renal failure (d)** is a well-known complication of rhabdomyolysis, primarily due to myoglobinuric nephropathy.
## **Why Each Wrong Option is Incorrect**
- **Option B:** While muscle rupture can occur in trauma leading to rhabdomyolysis, stating "calf muscles commonly ruptured" is too specific and does not broadly represent a feature of rhabdomyolysis. Muscle damage in rhabdomyolysis is not limited to or most commonly associated with calf muscles.
- **Option E:** **Hemoglobinuria** refers to the presence of hemoglobin in the urine, which is not a direct result of rhabdomyolysis. Rhabdomyolysis leads to myoglobinuria, not hemoglobinuria.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that rhabdomyolysis can lead to **myoglobinuric nephropathy**, a major cause of acute kidney injury. Early recognition and aggressive fluid resuscitation are crucial to prevent renal failure. Remember, the presence of **tea-colored urine** in a patient with muscle weakness or trauma should prompt investigation for rhabdomyolysis.
## **Correct Answer:** C. a, c, d.