**Core Concept**
The regression of Müllerian ducts in males is a critical process that occurs during fetal development, preventing the formation of female reproductive structures in males. This process involves the action of the anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance (MIS).
**Why the Correct Answer is Right**
The regression of Müllerian ducts in males is primarily mediated by the anti-Müllerian hormone (AMH), which is secreted by the Sertoli cells of the testes. AMH binds to its receptor, AMH type II receptor, on the surface of the Müllerian duct cells, leading to the inhibition of their growth and eventual regression. This process occurs between the 7th and 8th weeks of gestation, when the testes begin to produce AMH.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not relevant to the regression of Müllerian ducts in males.
**Option B:** This option is not a correct description of the process.
**Option C:** This option is not a correct timing for the regression of Müllerian ducts in males.
**Clinical Pearl / High-Yield Fact**
The regression of Müllerian ducts in males is a critical process that distinguishes males from females, and any failure of this process can lead to the formation of female reproductive structures in males, known as persistent Müllerian duct syndrome.
**Correct Answer: D.**
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