Medical MCQ - Regarding the lipid or liposomal formulations of amphotericin B, which of the following statments is accurate?

Regarding the lipid or liposomal formulations of amphotericin B, which of the following statments is accurate?

They are less expensive to use then conventional amphotericin B

They are more effective in funfal infections then conentonal preparations because they increase tissue uptake of amphotericin B

They may decrease the nephrotoxicity of amphotericin B

They have wider spectrum of antifungal activity than conventional formulations of ampheotericin B

Question Category:

Correct Answer:

They may decrease the nephrotoxicity of amphotericin B

Description:

(Ref: KDT 6/e p758) Newer liposomal preparations of amphotericin B have the following features: Less chances of nephrotoxicity and infusin related reactions Lesser uptake in the tissues like kidney More expensive Similar in efficacy and antifungal spectrum as conventional preparations

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