Regarding the lipid or liposomal formulations of amphotericin B, which of the following statments is accurate?

A. They are less expensive to use then conventional amphotericin B

B. They are more effective in funfal infections then conentonal preparations because they increase tissue uptake of amphotericin B

C. They may decrease the nephrotoxicity of amphotericin B

D. They have wider spectrum of antifungal activity than conventional formulations of ampheotericin B

Correct Answer: They may decrease the nephrotoxicity of amphotericin B

Description: (Ref: KDT 6/e p758) Newer liposomal preparations of amphotericin B have the following features: Less chances of nephrotoxicity and infusin related reactions Lesser uptake in the tissues like kidney More expensive Similar in efficacy and antifungal spectrum as conventional preparations

Category: Pharmacology

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