Pharmacology Regarding termination of drug action: A Drugs must be excreted from the body to terminate their action B Metabolism of drugs always abolishes their pharmacologic activity C Hepatic metabolism and renal excretion are the two most important mechanisms involved D Distribution of a drug out of blood stream terminates the drug's effects 💡 Explanation Regarding termination of drug action: ✓ Correct Answer: C. Hepatic metabolism and renal excretion are the two most important mechanisms involved