**Core Concept**
Retinoblastoma is a malignant tumor of the retina that primarily affects children, characterized by the uncontrolled growth of retinal cells. It can be hereditary or sporadic, and its progression is influenced by the tumor suppressor gene RB1.

**Why the Correct Answer is Right**
Retinoblastoma arises from the mutation of the RB1 gene, which codes for a protein that regulates cell cycle progression. The loss of RB1 function leads to the uncontrolled proliferation of retinal cells, resulting in tumor formation. The hereditary form of retinoblastoma is associated with the mutation of both alleles of the RB1 gene, while the sporadic form results from the mutation of a single allele.

**Why Each Wrong Option is Incorrect**
* **Option A:** This statement may be true, but it is not necessarily false regarding retinoblastoma.
* **Option B:** This is a true statement regarding retinoblastoma, making it an incorrect option.
* **Option C:** This statement is also true regarding retinoblastoma, making it an incorrect option.

**Clinical Pearl / High-Yield Fact**
Retinoblastoma is the most common intraocular malignancy in children, and early detection is crucial for effective treatment. The presence of leukocoria (white reflex) in a child's eye is a classic sign of retinoblastoma.

**Correct Answer:** B.
This statement is false regarding retinoblastoma.