Medicine Refractory gastric ulcer is defined as. A Ulcer that fails to heal despite 4 weeks of regular proper dose PPI B Ulcer that fails to heal despite 8 weeks of regular proper dose PPI C Ulcer that fails to heal despite 12 weeks of regular proper dose PPI D Ulcer that fails to heal despite 16 weeks of regular proper dose PPI 💡 Explanation Refractory gastric ulcer is defined as. ✓ Correct Answer: C. Ulcer that fails to heal despite 12 weeks of regular proper dose PPI