**Core Concept**
Reed-Sternberg cells are a characteristic histological feature of Hodgkin lymphoma, a type of cancer that affects the immune system. They are large, abnormal lymphocytes that play a crucial role in the pathogenesis of this disease.

**Why the Correct Answer is Right**
Reed-Sternberg cells are typically found in the lymphatic tissue, such as lymph nodes, and are characterized by their large size, abundant cytoplasm, and distinctive nuclear features, including a large, horseshoe-shaped nucleus and one or more prominent nucleoli. They are derived from B lymphocytes and are thought to arise from a genetic abnormality that leads to their characteristic appearance. The presence of Reed-Sternberg cells is a hallmark of Hodgkin lymphoma and is used as a diagnostic criterion.

**Why Each Wrong Option is Incorrect**
**Option A:** Reed-Sternberg cells are not typically associated with non-Hodgkin lymphoma, although some cases of lymphoblastic lymphoma may exhibit similar cellular features.
**Option B:** While Reed-Sternberg cells are derived from B lymphocytes, they are not characteristic of chronic lymphocytic leukemia (CLL), which typically involves small, mature B cells.
**Option C:** Reed-Sternberg cells are not found in the spleen or other organs outside of the lymphatic system.

**Clinical Pearl / High-Yield Fact**
Reed-Sternberg cells are a classic example of a "diagnostic cell" in hematology, and their presence is often used as a teaching tool to illustrate the importance of histological examination in the diagnosis of lymphoid malignancies.

**Correct Answer: C. Reed Sternberg cells are characteristically seen in Hodgkin lymphoma.**