**Core Concept**
Red man syndrome is a cutaneous adverse reaction to rapid infusion of certain medications, particularly vancomycin. It is characterized by flushing, erythema, and rash. The underlying mechanism involves histamine release and vasodilation.

**Why the Correct Answer is Right**
Vancomycin is a glycopeptide antibiotic that can cause red man syndrome due to its ability to release histamine from mast cells. This histamine release leads to increased vascular permeability, resulting in flushing, erythema, and rash. The syndrome is more common in patients with rapid infusion rates, which can overwhelm the body's ability to metabolize the histamine.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not specify a medication known to cause red man syndrome. While other medications may cause similar reactions, vancomycin is the most well-known and commonly associated with this condition.
**Option B:** This option is incorrect as it does not relate to the pathophysiology of red man syndrome. Histamine release is a key factor in the development of this syndrome, but it is not a direct cause.

**Clinical Pearl / High-Yield Fact**
To prevent red man syndrome, vancomycin should be infused slowly over at least 60 minutes. This allows for a more gradual release of histamine and reduces the risk of adverse reactions.

**Correct Answer: C. Vancomycin.**