All of the following are recognised features of Wilson’s disease except-
**Core Concept**
Wilson's disease, also known as hepatolenticular degeneration, is a rare genetic disorder characterized by excessive accumulation of copper in the body, particularly in the liver, brain, and other organs. This accumulation leads to damage and dysfunction of these organs, resulting in various clinical manifestations.
**Why the Correct Answer is Right**
Wilson's disease is typically inherited in an autosomal recessive pattern, with mutations in the ATP7B gene leading to impaired copper transport and regulation. The disease manifests with a range of symptoms, including liver disease (such as cirrhosis, hepatitis, and jaundice), neurological symptoms (such as tremors, muscle weakness, and psychiatric problems), and Kayser-Fleischer rings (copper deposits in the cornea). The diagnosis of Wilson's disease is often confirmed by laboratory tests, including low serum ceruloplasmin levels and elevated urinary copper excretion.
**Why Each Wrong Option is Incorrect**
**Option A:**
This option is incorrect because Wilson's disease is characterized by increased copper accumulation, not decreased copper levels.
**Option B:**
This option is incorrect because liver disease is a common feature of Wilson's disease, not a rare feature.
**Option C:**
This option is incorrect because Kayser-Fleischer rings are a hallmark of Wilson's disease, not a feature of another disease.
**Clinical Pearl / High-Yield Fact**
Wilson's disease should be considered in patients with unexplained liver disease, neurological symptoms, or Kayser-Fleischer rings, especially in those with a family history of the disease.
**Correct Answer: D.**