All of the following are recognised features of Wilson’s disease except –
**Core Concept**
Wilson's disease is a rare genetic disorder characterized by excessive accumulation of copper in the body, particularly in the liver, brain, and other vital organs. This accumulation leads to oxidative stress, mitochondrial dysfunction, and ultimately, cellular damage.
**Why the Correct Answer is Right**
Wilson's disease is caused by mutations in the ATP7B gene, which encodes a copper-transporting ATPase responsible for regulating copper levels in the body. The disease manifests with a range of symptoms, including liver disease, neurological symptoms, and psychiatric problems. Key features of Wilson's disease include:
* Kayser-Fleischer rings (copper deposition in the cornea)
* Hemolytic anemia
* Neuropsychiatric symptoms (e.g., tremors, rigidity, and personality changes)
* Liver disease (cirrhosis, hepatitis)
* Neurological symptoms (e.g., ataxia, dystonia)
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a feature of Wilson's disease. Instead, it is a characteristic of another condition.
**Option B:** While this option is a feature of Wilson's disease, it is not the only option, and another choice might be a better answer.
**Option C:** This is a classic feature of Wilson's disease, but there might be another option that is not a feature of the disease.
**Clinical Pearl / High-Yield Fact**
The Kayser-Fleischer rings are a hallmark of Wilson's disease, but they can also be seen in other conditions, such as primary biliary cirrhosis and idiopathic copper toxicosis.
**Correct Answer:** B.