Recently used topical NSAID for ophthalmic use
**Core Concept**
Topical NSAIDs for ophthalmic use are employed to reduce inflammation and pain in conditions such as uveitis, acute angle-closure glaucoma, and post-operative ocular surgery. This class of medications works by inhibiting the enzyme cyclooxygenase (COX), which is crucial in the synthesis of prostaglandins, key mediators of inflammation.
**Why the Correct Answer is Right**
The correct answer is a topical NSAID that is specifically used for ophthalmic purposes. Topical NSAIDs, such as flurbiprofen and ketorolac, are applied directly to the eye and have a minimal systemic absorption rate, reducing the risk of systemic side effects. They act by inhibiting COX-1 and COX-2 enzymes in the eye, thereby reducing the production of prostaglandins and other inflammatory mediators that contribute to pain and inflammation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not a commonly used topical NSAID for ophthalmic purposes.
**Option B:** This option is incorrect because it is a topical corticosteroid, not a NSAID, and is used for different indications in ophthalmology.
**Option C:** This option is incorrect because it is a systemic NSAID, not topical, and is not specifically used for ophthalmic conditions.
**Clinical Pearl / High-Yield Fact**
When choosing a topical NSAID for ophthalmic use, it is essential to consider the patient's medical history, particularly any history of systemic NSAID use or allergies, as well as the specific indication for treatment.
**Correct Answer: D. Flurbiprofen**