Furosemide acts to inhibit Na + reabsorption in which of the following locations
**Core Concept**
Furosemide is a loop diuretic that acts by inhibiting the reabsorption of sodium ions in the kidneys. This process is crucial for the regulation of electrolyte balance and fluid volume in the body.
**Why the Correct Answer is Right**
Furosemide specifically targets the thick ascending limb of the loop of Henle in the kidneys, where it inhibits the sodium-potassium-chloride cotransporter (NKCC2). This results in an increase in sodium and chloride delivery to the distal tubules and collecting ducts, leading to increased urine production. The inhibition of NKCC2 also leads to a decrease in potassium reabsorption, contributing to the hypokalemia often seen with loop diuretic use.
**Why Each Wrong Option is Incorrect**
**Option A:** The proximal convoluted tubule is primarily responsible for the reabsorption of glucose, amino acids, and other nutrients, but it is not the primary site of action for furosemide.
**Option B:** The distal convoluted tubule is involved in the regulation of potassium and hydrogen ion excretion, but it is not the primary site of action for furosemide.
**Option C:** The collecting duct is responsible for the fine-tuning of electrolyte balance, but it is not the primary site of action for furosemide.
**Clinical Pearl / High-Yield Fact**
Loop diuretics like furosemide are often used to treat edema associated with heart failure, liver disease, and nephrotic syndrome. They can also be used to manage hypertension and acute pulmonary edema.
**Correct Answer:** C. Thick ascending limb of the loop of Henle.