Rate limiting enzyme in cholesterol synthesis is:
Correct Answer: HMG -CoA reductase
Description: Hydroxymethylglutaryl-coenzyme A (HMG-CoA) is the precursor for cholesterol synthesis.HMG-CoA is also an intermediate on the pathway for synthesis of ketone bodies from acetyl-CoA.The enzymes for ketone body production are located in the mitochondrial matrix.HMG-CoA destined for cholesterol synthesis is made by equivalent, but different, enzymes in the cytosol. HMG-CoA is formed by condensation of acetyl-CoA and acetoacetyl-CoA, catalyzed by HMG-CoA Synthase.HMG-CoA Reductase is an integral protein of endoplasmic reticulum membranes. The catalytic domain of this enzyme remains active following cleavage from the transmembrane poion of the enzyme.The HMG-CoA Reductase reaction is rate-limiting for cholesterol synthesis
Category:
Biochemistry
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