**Core Concept**
Randomization is a statistical technique used to minimize bias in clinical trials and experiments by assigning participants to treatment or control groups in a way that is unpredictable and unrelated to any known factor that could influence the outcome. This helps to ensure that the groups are comparable in terms of relevant characteristics, reducing the risk of confounding variables affecting the results.

**Why the Correct Answer is Right**
The correct answer is a computer-generated random number sequence. This method of randomization uses a pseudorandom number generator to produce a sequence of numbers that appear to be random and unpredictable. By using a computer to generate the random numbers, it is possible to ensure that the sequence is truly random and unbiased, which is essential for maintaining the integrity of the experiment. This method is particularly useful in large-scale clinical trials where manual randomization can be impractical.

**Why Each Wrong Option is Incorrect**
**Option A:** Central randomization unit - While a central randomization unit can provide a secure and unbiased method of randomization, it is not the best method, as it may introduce delays and logistical challenges in large-scale trials.
**Option B:** Simple random sampling - This method of randomization is not suitable for clinical trials, as it does not take into account the complex variables that can affect the outcome of the experiment.
**Option C:** Stratified randomization - This method of randomization is useful for ensuring that the groups are balanced in terms of specific characteristics, but it is not the best method overall, as it can be complex to implement and may not account for all relevant variables.

**Clinical Pearl / High-Yield Fact**
Remember that randomization is a critical component of clinical trials, and the method used can significantly impact the validity of the results. Always use a computer-generated random number sequence to ensure that the randomization is truly unbiased and unpredictable.

**Correct Answer: D. Computer-generated random number sequence.**