True about dysgerminoma of ovary:a) Blood spread seenb) Schiller-Duval bodies seenc) Increase alfa fetoproteind) Bleomycin, etoposide and cisplatin givene) Radiosensitive
**Core Concept**
Dysgerminoma is a type of malignant germ cell tumor that arises from the ovary, accounting for approximately 40% of all ovarian germ cell tumors. It is a highly aggressive tumor that requires prompt treatment.
**Why the Correct Answer is Right**
Dysgerminoma is indeed radiosensitive, which means it responds well to radiation therapy. This property is crucial in the treatment of dysgerminoma, particularly in cases where surgical intervention is not feasible or has been unsuccessful. The radiosensitivity of dysgerminoma is attributed to its rapid cell division rate, making it more susceptible to radiation-induced damage.
**Why Each Wrong Option is Incorrect**
**Option A:** Blood spread seen - While dysgerminoma can metastasize through the bloodstream, this is not the most characteristic feature of this tumor. Metastasis typically occurs through the lymphatic system.
**Option B:** Schiller-Duval bodies seen - Schiller-Duval bodies are characteristic of yolk sac tumors, not dysgerminoma. They are a distinctive histological feature that helps in the differential diagnosis of germ cell tumors.
**Option C:** Increase alpha fetoprotein - Alpha fetoprotein (AFP) is a tumor marker that is typically elevated in yolk sac tumors and hepatocellular carcinomas, not dysgerminoma. The tumor marker of choice for dysgerminoma is lactate dehydrogenase (LDH).
**Option D:** Bleomycin, etoposide, and cisplatin given - While this combination of chemotherapy agents is effective in treating various types of germ cell tumors, it is not the primary treatment for dysgerminoma. The standard treatment for dysgerminoma involves surgical resection, followed by radiation therapy if necessary.
**Clinical Pearl / High-Yield Fact**
Dysgerminoma is a radiosensitive tumor, which is a critical fact to remember when planning treatment. It is essential to recognize the characteristic features of dysgerminoma to avoid misdiagnosis and to provide appropriate treatment.
**Correct Answer:** E. Radiosensitive