## **Core Concept**
Pyrantel pamoate is an anthelmintic medication used to treat parasitic worm infections. It works by inducing spastic paralysis of the worm's muscles, leading to its expulsion from the body. This drug is particularly effective against certain types of helminths.

## **Why the Correct Answer is Right**
The correct answer involves the effectiveness of pyrantel pamoate against specific types of helminths. Pyrantel pamoate is known for its efficacy against **Ascaris lumbricoides (roundworm)** and **hookworms (Ancylostoma duodenale and Necator americanus)**. It is not the first line for tapeworms or flukes, which are treated with other specific anthelmintics.

## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because while pyrantel pamoate is effective against some nematodes, the specific combination provided here does not accurately reflect its primary use.
- **Option B:** This option might seem plausible but does not accurately represent the primary effectiveness of pyrantel pamoate.
- **Option C:** This option is incorrect because it likely includes types of helminths (like tapeworms or flukes) that are not primarily treated with pyrantel pamoate.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that pyrantel pamoate is often used in treating **ascariasis** and **hookworm infections**. It is not effective against **cestodes (tapeworms)** or **trematodes (flukes)**, which require different treatments.

## **Correct Answer:** D. Ascaris and hookworm.