Pupil fails to dilate by giving cocaine in –

Correct Answer: Peripheral sympathetic paralysis.
Description: In periphery cocaine blocks the uptake of Adrenaline and Noradrenaline in Adrenergic nerve ending resulting in higher concentration of sympathetic neurotransmitters (Sympathomimetic effect) : The peripheral sympathomimetic action of cocaine produces following effect : Mydriasis Rise in B.P. Local vasoconstriction Tachycardia Therefore if the peripheral sympathetic system is paralysed it will lead to reverse of the above mentioned actions.
Category: Anaesthesia
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