A 5 years old boy punctures his thumb with a rusty nail. Four hours later, the thumb appears red and swollen. Initial swelling of boy’s thumb is primarily due to which of the following mechanism?
**Core Concept**
The initial swelling of the boy's thumb is primarily due to an inflammatory response caused by the introduction of foreign particles, such as bacteria and rust, into the tissue. This leads to the activation of various immune cells and the release of chemical mediators, resulting in increased blood flow and fluid leakage into the interstitial space.
**Why the Correct Answer is Right**
The correct answer is related to the **inflammatory response**, specifically the **exudative phase**. In this phase, increased vascular permeability allows plasma proteins and fluid to leak into the interstitial space, causing edema. This is mediated by the release of chemical mediators, such as histamine, bradykinin, and leukotrienes, which are produced by immune cells like mast cells and neutrophils.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because the initial swelling is not primarily due to the coagulation cascade. While coagulation does play a role in wound healing, it is not the primary mechanism responsible for the initial swelling.
* **Option B:** This option is incorrect because the initial swelling is not primarily due to the complement system. While the complement system does contribute to the inflammatory response, it is not the primary mechanism responsible for the initial swelling.
* **Option C:** This option is incorrect because the initial swelling is not primarily due to the humoral immune response. While the humoral immune response does play a role in wound healing, it is not the primary mechanism responsible for the initial swelling.
**Clinical Pearl / High-Yield Fact**
Remember that the exudative phase of inflammation is characterized by increased vascular permeability, leading to the leakage of plasma proteins and fluid into the interstitial space. This is a key concept to understand in the context of wound healing and the inflammatory response.
**Correct Answer:** C.