Pubey does NOT occur before the age of 8 years because:

A. The hypothalamus does not secrete GnRH in a pulsatile manner

B. Inadequate synthesis of gonadotropins by the pituitary

C. Gonads are unresponsive to gonadotropin

D. Positive feedback action of gonadal steroids on pituitary

Correct Answer: The hypothalamus does not secrete GnRH in a pulsatile manner

Description: Pubey and regulation of its onset During childhood the hypothalamus does not secrete significant amount of GnRH because during childhood, the slightest secretion of any sex steroid hormones exes a strong inhibitory effect on hypothalamic secretion of GnRH. But at the time of pubey, the secretion of hypothalamic GnRH breaks through the childhood inhibition and adult sexual life begins.

Category: Physiology

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