**Core Concept**
Psoriasis is a chronic inflammatory skin condition characterized by accelerated epidermal cell turnover, immune system dysregulation, and abnormal keratinocyte proliferation. The pathophysiology involves a complex interplay between keratinocytes, T lymphocytes, and various cytokines, leading to the formation of scaly, erythematous plaques.

**Why the Correct Answer is Right**
The correct answer is related to the characteristic features of psoriasis. Psoriasis typically presents with well-demarcated, scaly plaques, nail changes (pitting, onycholysis), and joint involvement (psoriatic arthritis). The condition is also associated with an increased risk of cardiovascular disease and depression.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a typical feature of psoriasis. While some patients may experience itching, it is not a universal symptom.
**Option B:** This option is incorrect because psoriasis is not primarily associated with a decrease in epidermal cell turnover. Instead, there is an increased rate of cell proliferation.
**Option C:** This option is not accurate. While psoriasis can affect the scalp, palms, and soles, it typically spares the face.

**Clinical Pearl / High-Yield Fact**
One important aspect of psoriasis management is the use of biologic agents, such as TNF-alpha inhibitors, which target specific pathways involved in the disease's pathophysiology.

**Correct Answer:** D.