**Core Concept**
Pseudogout, also known as calcium pyrophosphate deposition disease (CPPD), is a type of arthritis characterized by the deposition of calcium pyrophosphate dihydrate (CPPD) crystals within the joint space. This condition is often associated with large joints such as the knee, but it can also affect smaller joints in other contexts.

**Why the Correct Answer is Right**
Small joints, such as those in the hands or feet, are typically not affected in pseudogout. This is because the deposition of CPPD crystals is usually seen in larger joints, where the joint space is larger and the joint fluid is more susceptible to crystal accumulation. In contrast, small joints tend to be affected in other types of arthritis, such as rheumatoid arthritis. The correct answer is A, as small joints are not typically affected in pseudogout.

**Why Each Wrong Option is Incorrect**
**Option B:** Large joints are indeed commonly affected in pseudogout, particularly the knee. This is due to the larger joint space and the higher likelihood of CPPD crystal deposition.

**Option C:** Chondrocalcinosis, or the deposition of calcium salts within the cartilage, is a characteristic feature of pseudogout. This is often visible on X-ray as a "salt and pepper" appearance of the cartilage.

**Option D:** The deposition of calcium pyrophosphate is a hallmark of pseudogout. CPPD crystals are the primary cause of the inflammation and joint pain associated with this condition.

**Clinical Pearl / High-Yield Fact**
It's essential to note that pseudogout can be confused with other types of arthritis, particularly gout. However, gout is typically associated with the deposition of monosodium urate crystals, rather than CPPD crystals.

**✓ Correct Answer: A. Small joints affected**