**Core Concept**
An infected pancreatic pseudocyst is a serious complication that requires prompt and effective treatment to prevent further complications, such as abscess formation, sepsis, and even death. The treatment of choice involves a combination of antibiotics and drainage of the infected pseudocyst.

**Why the Correct Answer is Right**
The correct answer involves drainage of the infected pseudocyst, which can be achieved through endoscopic, percutaneous, or surgical methods. This approach helps to remove the infectious material, reduce the risk of further complications, and promote healing. The choice of drainage method depends on the size, location, and complexity of the pseudocyst, as well as the patient's overall condition.

**Why Each Wrong Option is Incorrect**
**Option A:** Antibiotics alone may not be sufficient to treat an infected pseudocyst, as they do not address the physical presence of the infectious material.
**Option B:** Aspiration of the pseudocyst through a needle may not be effective in removing the entire infected material, and may lead to recurrence or further complications.
**Option C:** Repeated endoscopic drainage may not be feasible or effective in the long term, and may lead to complications such as bleeding or perforation.

**Clinical Pearl / High-Yield Fact**
It is essential to note that the treatment of infected pancreatic pseudocyst should be individualized and managed by a multidisciplinary team of healthcare professionals, including gastroenterologists, surgeons, and infectious disease specialists.

**Correct Answer: D. Drainage of the infected pseudocyst, either through endoscopic, percutaneous, or surgical methods.**