**Core Concept**
Psammoma bodies are a type of calcification seen in certain neoplasms, characterized by concentrically laminated calcified structures. They are associated with **papillary thyroid carcinoma**, **serous ovarian cystadenocarcinoma**, and **meningioma**. The presence of psammoma bodies is a diagnostic clue to the underlying pathology.
**Why the Correct Answer is Right**
The correct answer is based on the specific tumors that are known to have psammoma bodies. **Papillary thyroid carcinoma** often contains psammoma bodies, which are a hallmark of this cancer. **Serous ovarian cystadenocarcinoma** and **meningioma** also frequently exhibit psammoma bodies.
**Why Each Wrong Option is Incorrect**
**Option A:** Papillary thyroid carcinoma is incorrect because it is a tumor known to have psammoma bodies.
**Option B:** Serous ovarian cystadenocarcinoma is incorrect because psammoma bodies can be found in this type of ovarian cancer.
**Option C:** Meningioma is incorrect as it is another type of tumor associated with psammoma bodies.
**Clinical Pearl / High-Yield Fact**
Psammoma bodies are a key diagnostic feature that can help narrow down the differential diagnosis when encountered in a pathology specimen. Recognizing these structures can aid in the identification of specific types of cancers.
**Correct Answer:** D.
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