Prucalopride drug is ?
Correct Answer: 5HT4 agonist
Description: Ans. A. 5HT4 agonist* Prucalopride is a drug acting as a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.* Approved for use in Europe in 2009.* Prucalopride, a first in class dihydro-benzofuran-carboxamide, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities.* Prucalopride alters colonic motility patterns serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.* The observed effects are exeed highly selective action on 5-HT4 receptor.* Prucalopride has >150-fold higher affinity for 5-HT4 receptors than for other receptors.
Category:
Pharmacology
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