Proton pump inhibitors are most effective when they are given –
Correct Answer: Sholy before meals
Description: Ans. is 'b' i.e., Sholy before meals o Bioavailibility of all PPIs is reduced by food; they should be taken in empty stomach, followed 1 hour later by a meal to activate 1-1+ ATPase and make it more susceptible to the PPI. o PPIs should be administered approximately 1 hour before a meal (usually breakfast) so that the peak serum concentration coincides with the maximal activity of proton pump secretion.
Category:
Pharmacology
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