Drug which inhibit protein synthesis are all of the following except: March 2007
**Core Concept**
Protein synthesis inhibitors are a class of antimicrobial and antineoplastic agents that target the process of protein synthesis in microorganisms or cancer cells. These drugs work by binding to specific targets within the ribosome or other components of the protein synthesis machinery, thereby preventing the translation of messenger RNA into a polypeptide chain.
**Why the Correct Answer is Right**
The correct answer is a drug that does not inhibit protein synthesis. This class of drugs includes antibiotics such as beta-lactams (e.g., penicillins, cephalosporins), which work by inhibiting cell wall synthesis, and macrolides (e.g., erythromycin), which work by inhibiting protein synthesis by binding to the 50S ribosomal subunit. However, the correct answer is a drug that targets a different mechanism of action.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a drug that inhibits protein synthesis by binding to the 30S ribosomal subunit. It is an aminoglycoside antibiotic.
**Option B:** This option is incorrect because it is a drug that inhibits protein synthesis by binding to the 50S ribosomal subunit. It is a macrolide antibiotic.
**Option C:** This option is incorrect because it is a drug that inhibits protein synthesis by binding to the 50S ribosomal subunit. It is a lincosamide antibiotic.
**Clinical Pearl / High-Yield Fact**
It's worth noting that the mechanism of action of protein synthesis inhibitors can be complex, and some drugs may have multiple mechanisms of action.
**Correct Answer: D.**